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Research activities

par root - publié le , mis à jour le

 

We are interested in the self-assembly properties of biological macromolecules and living cells, principally bacteria. These are complex systems characterized by their soft matter and polyelectrolyte properties.
Three main topics are currently being developped :
- Self assembly in condensed DNA and chromatin in vitro and in vivo
- Physical virology
- Collective behaviour of bacteria

 

CONDENSED DNA & CHROMATIN


PHYSICAL VIROLOGY


BACTERIA AND BIOFILMS


 

We develop the methods necessary :

  • to follow the dynamics of our systems (time-resolved SAXS, light scattering, fluorescence microscopy)
  • to visualize individual molecules and nano-objects in native conditions (cryo-electron microscopy)
  • to image cells and hydrated dense materials at high resolution by freeze-fracture and cryo-electron microscopy of vitreous sections (CEMOVIS)

 

IMAGING THE CELL AT HIGH RESOLUTION


CYO-ELECTRON MICROSCOPY


TIME-RESOLVED SAXS


MICROFLUIDICS


We also take advantage of fruitful collaborations and the large-scale facilities available in the vicinity of Orsay to explore the soft matter at the nanoscale :

  • Laboratoire Léon Brillouin (Saclay) : small-angle neutron scattering on the PAXY beamline.
  • Soleil synchrotron (Gif-sur-Yvette) : small-angle x-ray scattering on the SWING beamline.